Linezolid Impurity 120 TFA CAS 333753-69-8 (free base)
| CAS No. | 333753-69-8 (free base) |
| Molecular Formula | C15H22FN3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Linezolid Impurity 120 TFA.
Linezolid Impurity 120 TFA (CAS 333753-69-8 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C15H22FN3O3C2HF3O2 and a molecular weight of 425.38 g/mol.
Linezolid Impurity 120 TFA (C15H22FN3O3C2HF3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Linezolid Impurity 120 TFA meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H22FN3O3 C2HF3O2 |
| Molecular Weight | 425.38 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Linezolid Standards
- Linezolid -D8 (CAS 1032182-14-1)
- Linezolid Impurity 69 (CAS 10389-51-2)
- Linezolid-d3 (CAS 1127120-38-0)
- Linezolid Impurity 58 (CAS 1175797-88-2)
- Linezolid Impurity 11 (CAS 1215006-08-8)
- Linezolid Impurity 12 (CAS 1215006-11-3)
- Linezolid Impurity 9 (CAS 1219708-30-1)
- Linezolid Impurity 78 HCI (CAS 1233093-70-3(free base))
Recommended Standards
- Sitagliptin Impurity 81 (CAS 2248445-08-9)
- Ketorolac EP Impurity A (CAS 154476-25-2)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
- n-[4-(1-aminoethyl)phenyl]-4-fluorobenzamide (CAS 954269-93-3)
- 1-Isobutylcyclopropanecarboxylic Acid (CAS 1346641-21-1)
- 3-(3-Bromo-5-fluorophenoxy)propanenitrile (CAS 1379304-08-1)
- Triptorelin-d5 Trifluoroacetic Acid Salt (CAS CATO-C4X-18621)
- n-(3-Fluorophenyl)-2-[n-methyl-1-(1-oxo-3-phenyl-3,4-dihydro-1h-2-benzopyran-6-yl)formamido]acetamide (CAS 920681-62-5)
- 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)thioxomethyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione (CAS 1333233-46-7)
- Semaglutide (CAS 910463-68-2（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com